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Second generation antihistamines include cetirizine hydrochloride (Zyrtec), loratadine (Claritin, Claratyne), fexofenadine hydrochloride (Allegra, Telfast), and desloratadine (Claramax, Clarinex).Confusingly, these are sometimes also referred to as third generation antihistamines.Second generation antihistamines are effective in treating both seasonal allergic rhinitis (hayfever) and perennial allergic rhinitis.They are also particularly useful for treating a condition known as chronic idiopathic urticaria.
For example, cetirizine can be more effective at relieving allergy symptoms, especially controlling itching and swelling.They have the added benefit that they usually only need to be taken one or twice daily to be effective.Cetirizine and loratadine are once daily antihistamines, while fexofenadine is taken once or twice daily, depending on its strength.They are all effective antihistamines that are less sedating and have relatively few side effects.
Second generation antihistamines are less likely to cause impairment of cognitive facilities or performance skills.
Second generation antihistamines are non-sedating medications that work by preventing the actions of histamine.